Caspase 10 Antibody

Catalog Number:

33328

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q92851
NCBI Gene ID: 843

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Caspase 10.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Caspase 10 protein.

Applications:

WB IHC IF

Background:

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive.

Frank C. Kischkel, J. Biol. Chem., Nov 2001; 276: 46639 - 46646.
Ingo H. Engels, Mol. Cell. Biol., Apr 2005; 25: 2808 - 2818.
Daniela Sciaky, J. Immunol., Apr 2000; 164: 3806.
Jin Wang, PNAS, Nov 2001; 98: 13884.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF