LAT (Ab-255) Antibody

Catalog Number:

33313

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O43561
NCBI Gene ID: 27040

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human LAT around the phosphorylation site of tyrosine 255.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total LAT protein.

Applications:

WB

Background:

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Zhang W., Cell 92:83-92(1998).
Martin J., Nature 432:988-994(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF