Epo-R (Ab-426) Antibody

Catalog Number:

33312

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P19235
NCBI Gene ID: 2057

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human Epo-R.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Epo-R protein.

Applications:

WB

Background:

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.

Winkelmann J.C., Blood 76:24-30(1990) [PubMed: 2163695].
Jones S.S.,Blood 76:31-35(1990) [PubMed: 2163696].
Noguchi C.T., Blood 78:2548-2556(1991) [PubMed: 1668606].

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF