TPH2 (Ab-19) Antibody

Catalog Number:

33305

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q8IWU9
NCBI Gene ID: 121278

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human TPH2 around the phosphorylation site of serine 19 (G-FI-S(p)-L-D).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TPH2 protein.

Applications:

WB

Background:

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Bader M., Science 299:76-76(2003).
Gibbs R.A., Nature 440:346-351(2006).
Pandey A., Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF