FADD (Ab-191) Antibody

Catalog Number:

33299

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q61160/Q13158
NCBI Gene ID: 14082

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human FADD.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FADD protein.

Applications:

WB

Background:

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis By similarity. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling By similarity.

Zhang J., Mol. Cell. Biol. 16:2756-2763(1996).
Hsu H., Cell 84:299-308(1996).
Carninci P., Science 309:1559-1563(2005)

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF