BL-CAM (Ab-807) Antibody

Catalog Number:

33260

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P20273
NCBI Gene ID: 933

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human BL-CAM around the phosphorylation site of tyrosine 807 (G-D-Y(p)-E-N).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total BL-CAM protein.

Applications:

WB

Background:

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Wilson G.L., J. Exp. Med. 173:137-146(1991).
Wilson G.L., J. Immunol. 150:5013-5024(1993).
Stamenkovic I., Nature 345:74-77(1990).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF