FIR Antibody

Catalog Number:

33622

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O94887
NCBI Gene ID: 9855

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human FIR.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FIR protein.

Applications:

WB

Background:

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity.

Nagase T., DNA Res. 5:31-39(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Jandrig B., Oncogene 23:9295-9302(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF