Tau (Ab-717/400) Antibody

Catalog Number:

33223

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P10636
NCBI Gene ID: 4137

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of serine 717/400 (V-V-S(p)-G-D).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Tau protein.

Applications:

WB

Background:

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Goedert M.,Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).
Goedert M.,EMBO J. 8:393-399(1989).
Lee G.,Neuron 2:1615-1624(1989).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF