CREB (Ab-100) Antibody

Catalog Number:

33210

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P16220
NCBI Gene ID: 1385

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human CREB around the phosphorylation site of threonine 100 (S-G-T(p)-Q-I).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CREB protein.

Applications:

WB

Background:

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Berkowitz L.A., Proc. Natl. Acad. Sci. U.S.A. 87:5258-5262(1990).
Yoshimura T., EMBO J. 9:2537-2542(1990).
Waeber G., Trans. Assoc. Am. Physicians 103:28-37(1990).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF