APC1 Antibody

Catalog Number:

33263

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9H1A4
NCBI Gene ID: 64682

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human APC1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total APC1 protein.

Applications:

IHC

Background:

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Joergensen P.M., Gene 262:51-59(2001).
Ota T., Nat. Genet. 36:40-45(2004).
Kraft C., EMBO J. 22:6598-6609(2003).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF