APC Antibody

Catalog Number:

33153

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P25054
NCBI Gene ID: 324

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human APC.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total APC protein

Applications:

IHC

Background:

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Matthew Bjerknes, Am. J. Pathol., Jun 1999; 154: 1831.
T Maltzman, Carcinogenesis, Dec 1997; 18: 2435 - 2439.
Jean Schneikert, Hum. Mol. Genet., Jan 2007; 16: 199 - 209.
Dhaval M. Patel, J. Immunol., Nov 1999; 163: 5201

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF