GR (Ab-226) Antibody

Catalog Number:

33132

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P04150
NCBI Gene ID: 2908

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human GR around the phosphorylation site of serine 226/234/246 (L-L-S-P-L).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GR protein.

Applications:

WB IHC

Background:

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Kyung Jin Kwak, J. Exp. Bot., Nov 2005; 56: 3007 - 3016.
Maite de Llanos, Hum. Reprod., Jan 2005; 20: 216 - 220.
M. Lynch, Mol. Hum. Reprod., Jul 2005; 11: 507 - 512.
Valeriya P. Makarenkova, J. Immunol., Feb 2006; 176: 2085 - 2094.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF