GR (Ab-211) Antibody

Catalog Number:

33123

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P04150
NCBI Gene ID: 2908

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human GR around the phosphorylation site of serine 211 (N-E-S-P-W).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GR protein.

Applications:

WB IHC IF

Background:

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Zhen Wang, Mol. Endocrinol., Mar 2007; 21: 625 - 634.
Aaron L. Miller, Mol. Endocrinol., Jun 2005; 19: 1569 - 1583.
Paul J. LeBlanc, J. Physiol., Jun 2004; 557: 559 - 570.
Jos¨¦ Xavier-Neto, Hypertension, Jul 1999; 34: 31.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF