POLI Antibody

Catalog Number:

32510

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UNA4
NCBI Gene ID:11201

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human POLI.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total POLI protein.

Applications:

WB

Background:

Mammalian Pol ι owns an unusual combination of properties: it is stimulated by Mn2+ ions, can bypass some DNA lesions and misincorporates ¡°G¡± opposite template ¡°T¡± more frequently than incorporates the correct ¡°A.¡± It also was shown to possess dRP lyase activity. In addition, Pol ι is much more efficient in the presence of Mn2+ in comparison to Mg2+. . It has been proposed that POLI involves in immunoglobulin somatic hypermutation (SHM), bypass of deaminated cytosines, several adducts of the purine bases. DNA strand crosslinks and is involved in DNA repair under oxidative stress.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF