CD46 Antibody

Catalog Number:

32368

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P15529
NCBI Gene ID:4179

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human CD46.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total CD46 protein.

Applications:

WB

Background:

CD46 is a type I membrane protein and a regulatory part of the complement system. This protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, CD46 can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, this protein may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 is found in a cluster on chromosome 1q32 with other proteins that are structural components of the complement system. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF