EDARADD antibody

Catalog Number:

31818

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O00203
NCBI Protein#: BC128082

Form of Antibody:

pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Storage/Stability:

Immunogen:

Full length fusion protein

Purification:

Antigen affinity purification

Specificity/Sensitivity:

Applications:

IHC

Background:

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.?

References:

appl_detail:

IHC dilution:1:35-1:200

Datasheet PDF