SAV1 Polyclonal Antibody

Catalog Number:

31794

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9H4B6
NCBI Gene ID:60485

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human SAV1 (NP_068590.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

References:

appl_detail:

WB 1:1000 - 1:4000

Datasheet PDF