BMP7 Antibody

Catalog Number:

32087

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P18075
NCBI Gene ID:655

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human BMP7.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total BMP7 protein.

Applications:

WB

Background:

Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation (1,2). BMPs belongs to the TGF-β superfamily, playing many diverse functions during development (3). BMPs are synthesized as precursor proteins and then processed by cleavage to release the c-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5 and 8), resulting the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems (3,4). BMP7, also known as osteogenic protein-1 (OP-1), is found to be upregulated in some cancer cells (5-7), and may play a role in cancer metastasis (7-9).

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF