FBXW4 Polyclonal Antibody

Catalog Number:

31453

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P57775
NCBI Gene ID:6468

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human FBXW4 (NP_071322.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF