PARP1 Antibody

Catalog Number:

31288

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P09874
Gene ID:142

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 12-21 amino acids of human poly (ADP-ribose) polymerase 1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PARP1 protein.

Applications:

ELISA WB IHC

Background:

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

References:

appl_detail:

Predicted MW: 113kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Datasheet PDF