VEGFA Antibody

Catalog Number:

31274

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P15692
Gene ID:7422

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 130-143 amino acids of human vascular endothelial growth factor A

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total VEGFA protein.

Applications:

ELISA WB IHC

Background:

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

References:

appl_detail:

ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:100

Datasheet PDF