RNF126 Antibody

Catalog Number:

31265

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9BV68
Gene ID:55658

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 106-119 amino acids of Human ring finger protein 126

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total RNF126 protein.

Applications:

ELISA WB IHC

Background:

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF126 interacts with p21 and RNF126 over-expression increased p21 protein ubiquitination in an E3 ligase activity-dependent manner. RNF126 knockdown induced loss of cell viability in MDA-MB-231 and PC-3 can be partially rescued by depletion of p21. RNF126 stable knockdown in PC3 inhibited tumor growth in SCID mice.

References:

appl_detail:

Predicted MW: 38kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:100

Datasheet PDF