RAD50 Antibody

Catalog Number:

31264

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q92878
Gene ID:10111

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 325-339 amino acids of Human RAD50 homolog (S. cerevisiae)

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total RAD50 protein.

Applications:

ELISA WB IHC

Background:

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

References:

appl_detail:

Predicted MW: 154kd
ELISA: 1:2000-1:10000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Datasheet PDF