PRMT5 Antibody

Catalog Number:

31262

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q06830
Gene ID:5052

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide peptide corresponding to a region derived from 622-637 amino acids of human protein arginine methyltransferase 5

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PRMT5 protein.

Applications:

ELISA WB IHC

Background:

Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.

References:

appl_detail:

Predicted MW: 71kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:15-1:50

Datasheet PDF