NFASC Antibody

Catalog Number:

31250

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O94856; NCBI Gene#: 23114; NCBI Protein#: NP_001005388

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 1225-1240 amino acids of human neurofascin

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total NFASC protein.

Applications:

WB

Background:

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

References:

appl_detail:

Predicted MW: 150kd
Western blotting: 1:200-1:1000
 

Datasheet PDF