POMC Antibody

Catalog Number:

31243

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P61981
Gene ID:7532

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide peptide corresponding to a region derived from 136-150 amino acids of human proopiomelanocortin

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total POMC protein.

Applications:

ELISA WB

Background:

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.

References:

appl_detail:

Predicted MW: 29kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF