MMP11 Antibody

Catalog Number:

31240

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P01189
Gene ID:5443

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 470-488 amino acids of Human matrix metallopeptidase 11 (stromelysin 3)

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total MMP11 protein.

Applications:

ELISA WB

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

References:

appl_detail:

Predicted MW: 55kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF