GFRA2 Antibody

Catalog Number:

31206

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P11169
Gene ID:6515

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 378-392 amino acids of Human GDNF family receptor alpha 2

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total GFRA2 protein.

Applications:

ELISA WB

Background:

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Predicted MW: 51kd
ELISA: 1:1000-1:5000
Western blotting: 1:200-1:1000

Datasheet PDF