DDB1 Antibody

Catalog Number:

31182

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9NRI5
Gene ID:27185

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 1125-1140 amino acids of Human DNA damage-binding protein 1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total DDB1 protein.

Applications:

ELISA WB IHC

Background:

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

References:

appl_detail:

Predicted MW: 127kd
ELISA: 1:500-1:5000
Western blotting: 1:200-1:500
Immunohistochemistry: 1:25-1:100

Datasheet PDF