CDC6 Antibody

Catalog Number:

31169

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q14194
Gene ID:1400

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 18-32 amino acids of human cell division cycle 6 homolog (S. cerevisiae)

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CDC6 protein.

Applications:

ELISA WB IHC

Background:

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

References:

appl_detail:

Predicted MW: 63kd
ELISA: 1:1000-1:5000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100

Datasheet PDF