CCR8 Antibody

Catalog Number:

31168

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P08779
Gene ID:3868

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 175-191 amino acids of Human C-C chemokine receptor type 8

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CCR8 protein.

Applications:

ELISA WB

Background:

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.

References:

appl_detail:

Predicted MW: 41kd
ELISA: 1:1000-1:5000
Western blotting: 1:200-1:1000

Datasheet PDF