CTNNB1 Antibody

Catalog Number:

31164

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P51685
Gene ID:1237

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 757-770 amino acids of Human Catenin beta-1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CTNNB1 protein.

Applications:

ELISA WB

Background:

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[

References:

appl_detail:

Predicted MW: 86kd
ELISA: 1:500-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF