SMARCA4 Antibody

Catalog Number:

31163

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q92583
Gene ID:6361

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 1460-1474 amino acids of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member?

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total SMARCA4 protein.

Applications:

ELISA WB

Background:

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Predicted MW: 185kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF