PSMD3 Antibody

Catalog Number:

31119

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P29350
Gene ID:5777

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to C terminal 250 amino acids of human proteasome (prosome, macropain) 26S subunit, non-ATPase, 3

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PSMD3 protein.

Applications:

ELISA WB IHC

Background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count.

References:

appl_detail:

Predicted MW: 61kd
ELISA: 1:1000-1:5000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200

Datasheet PDF