IDE Antibody

Catalog Number:

31087

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q16891
Gene ID:10989

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a C terminal 300 amino acids of human insulin-degrading enzyme

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total IDE protein.

Applications:

ELISA WB

Background:

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

References:

appl_detail:

Predicted MW: 118kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF