GRK4 Antibody

Catalog Number:

31076

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8WW32
Gene ID:127540

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 36-145 amino acids of human G protein-coupled receptor kinase 4

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total GRK4 protein.

Applications:

ELISA WB IHC

Background:

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

References:

appl_detail:

Predicted MW: 66kd
ELISA: 1:2000-1:10000
Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:50-1:200

Datasheet PDF