DOK3 Antibody

Catalog Number:

31067

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q13115
Gene ID:1846

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to C terminal 300 amino acids of human docking protein 3

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total DOK3 protein.

Applications:

ELISA WB IHC

Background:

DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function

References:

appl_detail:

Predicted MW: 53kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:10-1:50

Datasheet PDF