CEACAM1 Antibody

Catalog Number:

31056

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8WXI8
Gene ID:338339

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 145-413 amino acids of human carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CEACAM1 protein.

Applications:

ELISA WB IHC

Background:

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.

References:

appl_detail:

Predicted MW: 51kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:15-1:50

Datasheet PDF