NFKBID Antibody

Catalog Number:

31018

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95998
Gene ID:10068

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 1-221 amino acids of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total NFKBID protein.

Applications:

ELISA WB IHC

Background:

May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.IκBNS, the nuclear IκB-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.IκBNS has been identified as a member of the IκB family of NF-κB inhibitors, which undergoes induction upon TCR signaling. IκBNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine.

References:

appl_detail:

Predicted MW: 33kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:100

Datasheet PDF