CASP1 Antibody

Catalog Number:

31012

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P25445
Gene ID:355

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CASP1 protein.

Applications:

ELISA WB IHC

Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

References:

appl_detail:

Predicted MW: 45kd
ELISA: 1:1000-1:10000
Western blotting: 1:1000-1:4000
Immunohistochemistry: 1:25-1:100

Datasheet PDF