YWHAE Antibody

Catalog Number:

31003

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95994
Gene ID:10551

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to C terminal 254 amino acids of Human Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total YWHAE protein.

Applications:

ELISA WB IHC

Background:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.

References:

appl_detail:

Predicted MW: 29kd
ELISA: 1:500-1:10000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:150

Datasheet PDF