CDK8 Polyclonal Antibody

Catalog Number:

30655

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P49336
NCBI Gene ID:1024

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human CDK8 (NP_001251.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

WB 1:500 - 1:2000
IP 1:50 - 1:100

Datasheet PDF